Identification and functional characterization of T-cell exhaustion-associated lncRNA AL031775.1 in osteosarcoma: a novel therapeutic target
This study identifies a novel six-lncRNA prognostic model and highlights the therapeutic potential of AL031775.1 in managing osteosarcoma by enhancing T-cell immunity and counteracting tumor progression. Targeting AL031775.1 represents a promising approach to improve immunotherapy efficacy in osteosarcoma. These findings provide critical insights into the molecular regulation of T-cell exhaustion and suggest a new avenue for therapeutic intervention.
Authors
- Guowen Huang
- Keying Guo (ORCID: https://orcid.org/0000-0001-6383-6321)
- Qi Chen (ORCID: https://orcid.org/0000-0002-6510-907X)
- Jinghong Yuan (ORCID: https://orcid.org/0000-0002-5180-8646)
- Shengqin Li
- Jingyu Jia (ORCID: https://orcid.org/0000-0001-7128-2621)
- Junchao Zhu (ORCID: https://orcid.org/0009-0004-4616-266X)
- Zhen Zhang (ORCID: https://orcid.org/0000-0003-4673-773X)
- Yameng Wang (ORCID: https://orcid.org/0009-0005-7405-1374)
- Shahrzad Arya (ORCID: https://orcid.org/0009-0002-2451-7584)
- Xijuan Liu (ORCID: https://orcid.org/0009-0009-7657-0281)
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Cedars-Sinai Medical Center (US)
- Nanchang University (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1517971
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94