Combined effects of cannabidiol and Δ9-tetrahydrocannabinol alleviate migraine-like symptoms in mice
A 100:1 ratio of CBD:THC has a beneficial effect on some of the most bothersome migraine-related symptoms in three mouse models. Our findings support a potential therapeutic efficacy of combined CBD and THC treatments.
Authors
- Anne‐Sophie Wattiez (ORCID: https://orcid.org/0000-0002-4392-2211)
- Arn M. J. M. van den Maagdenberg (ORCID: https://orcid.org/0000-0002-9310-5535)
- Adisa Kuburas (ORCID: https://orcid.org/0009-0000-1121-7932)
- William C. Castonguay
- Maarten Schenke
- Jayme S. Waite
- Georgii Krivoshein (ORCID: https://orcid.org/0000-0003-4737-5099)
- Erik Zorrilla (ORCID: https://orcid.org/0000-0003-1666-9959)
- Andrew F. Russo
- Anisa Dehghani (ORCID: https://orcid.org/0000-0002-7117-4599)
- Harold C. Flinn
- Sandra H. van Heiningen
- Else A. Tolner (ORCID: https://orcid.org/0000-0002-6501-9971)
- Christian Pina (ORCID: https://orcid.org/0009-0006-4252-6686)
Institutions
- University of Iowa (US)
- Leiden University Medical Center (NL)
- Department of Veterans Affairs (AU)
Publication Details
- Journal
- Cephalalgia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1177/03331024251314487
- Citations
- 10
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 13.94
Funders
- U.S. Department of Veterans Affairs
- Migraine Research Foundation
- Eli Lilly and Company
- Pfizer
- H. Lundbeck A/S
- Medical Delta
- National Institutes of Health