NCX1 interacts with TRPA1 to promote cell proliferation and tumor growth of colon cancer via disruption of calcium homeostasis
TRPA1 channels couple with the Ca<sup>2+</sup> exit mode of NCX1 to maintain a moderate increase in [Ca<sup>2+</sup>]<sub>cyt</sub> in CC cells, thereby promoting CC cell proliferation and tumor growth through ERK1/2 and β-catenin phosphorylation. Consequently, the NCX1/TRPA1 coupling may serve as an innovative target for preventing and treating CC.
Authors
- Ruihong Guo
- Guolong Zhou
- Junhui Li (ORCID: https://orcid.org/0000-0002-0127-2484)
- Liya Zhou (ORCID: https://orcid.org/0009-0007-9694-0492)
- Hui Dong
Institutions
- Qingdao University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1016/j.jare.2025.02.031
- Citations
- 2
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 2.93
Funders
- National Natural Science Foundation of China