Astragali Radix-Curcumae Rhizoma normalizes tumor blood vessels by HIF-1α to anti-tumor metastasis in colon cancer
This study presents novel findings that AC can regulate glycolysis through the inhibition of HIF-1α nuclear translocation, thereby promoting the normalization of tumor blood vessels and effectively inhibiting tumor metastasis. These results suggested that AC may serve as an effective therapeutic agent for normalizing tumor blood vessels.
Authors
- Zhongqing Liang (ORCID: https://orcid.org/0000-0003-1362-6363)
- Ruolan Sun (ORCID: https://orcid.org/0000-0002-3217-043X)
- Fan Zhao (ORCID: https://orcid.org/0000-0001-9325-1084)
- Yong Bian
- Yan Liang
- Xiying Tan (ORCID: https://orcid.org/0000-0002-5414-7871)
- Tingting Su (ORCID: https://orcid.org/0000-0002-1053-8352)
- Xu Wang (ORCID: https://orcid.org/0000-0003-4254-9416)
- Shijiao Zhu
- Zengyaran Yue
- Decai Tang
- Jiahui Qin
- G. George Yin (ORCID: https://orcid.org/0009-0009-8449-6245)
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1016/j.phymed.2025.156562
- Citations
- 7
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 6.55
Funders
- National Natural Science Foundation of China