Mitochondria and Cognition: An [18F]BCPP-EF Positron Emission Tomography Study of Mitochondrial Complex I Levels and Brain Activation During Task Switching
Higher mitochondrial complex I levels may underlie an individual's ability to exhibit a stronger BOLD response during task switching and are associated with better task-switching performance. This provides the first evidence linking the BOLD response with mitochondrial complex I and suggests a possible biological mechanism for the aberrant BOLD response in conditions associated with mitochondrial complex I dysfunction that should be tested in future studies.
Authors
- Oliver Howes (ORCID: https://orcid.org/0000-0002-2928-1972)
- Eugenii A. Rabiner (ORCID: https://orcid.org/0000-0003-3612-6687)
- Ekaterina Shatalina (ORCID: https://orcid.org/0000-0001-8900-0792)
- Alex Whittington
- Ellis Chika Onwordi (ORCID: https://orcid.org/0000-0001-8108-1225)
- Thomas Whitehurst (ORCID: https://orcid.org/0000-0002-7005-902X)
- Sridhar Natesan (ORCID: https://orcid.org/0000-0001-7499-1714)
- Roger N. Gunn (ORCID: https://orcid.org/0000-0003-1181-5769)
- Matthew B. Wall (ORCID: https://orcid.org/0000-0002-0493-6274)
- Matthew M. Nour (ORCID: https://orcid.org/0000-0003-0858-6184)
- Tiago Reis Marques (ORCID: https://orcid.org/0000-0003-0602-7661)
- Ayla Mansur (ORCID: https://orcid.org/0000-0002-2512-5745)
- Atheeshaan Arumuham (ORCID: https://orcid.org/0000-0001-9018-0305)
Institutions
- Queen Mary University of London (GB)
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- East London NHS Foundation Trust (GB)
- Invicro (United Kingdom) (GB)
- Oxford Centre for Computational Neuroscience (GB)
- MRC London Institute of Medical Sciences (GB)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Biological Psychiatry Cognitive Neuroscience and Neuroimaging
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1016/j.bpsc.2025.02.007
- Citations
- 1
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- King’s College London
- South London and Maudsley NHS Foundation Trust
- Wellcome Trust
- Maudsley Charity
- National Institute for Health and Care Research
- Medical Research Council