Korean black ginseng extract alleviates Alzheimer's disease-related cognitive impairment by activating the Nrf2/HO-1 pathway and suppressing the p38 MAPK/NF-κB/STAT3 pathways and NLRP3 inflammasome via TLR2 and TLR4 modulation
Taken together, BGE could improve AD-related cognitive decline and neurodegeneration by simultaneously regulating anti-inflammatory pathways (p38 MAPK/NF-κB/STAT3 and NLRP3 inflammasome) and an antioxidant pathway (Nrf2/HO-1) via modulation of TLR2/4.
Authors
- Yujeong Ha (ORCID: https://orcid.org/0000-0002-9109-2240)
- Sang‐Kwan Moon (ORCID: https://orcid.org/0000-0003-0497-3080)
- Jong Kil Lee (ORCID: https://orcid.org/0000-0002-2428-3530)
- Tae Woo Kwon (ORCID: https://orcid.org/0000-0003-2417-9458)
- Ik‐Hyun Cho (ORCID: https://orcid.org/0000-0002-1036-0494)
- Seung-Yeol Nah (ORCID: https://orcid.org/0000-0001-9697-4763)
- Ji Hoon Jung (ORCID: https://orcid.org/0000-0002-5644-5960)
- Min Soo Kim (ORCID: https://orcid.org/0000-0003-1892-8061)
- Seung Ho Jeon (ORCID: https://orcid.org/0000-0001-7992-0448)
- Hyo-Sung Jo
Institutions
- Konkuk University (KR)
- Kyung Hee University (KR)
- Korea Institute of Brain Science (KR)
- Kyung Hee University Medical Center (KR)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1016/j.jgr.2025.02.002
- Citations
- 9
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- National Research Foundation Singapore