Regulating chemoresistance and cancer stemness: the CDH17-YAP pathway in distinct cellular states of lung cancer CTC clusters
The results indicate that lung CTC clusters with stem cell-like properties exhibit chemoresistance, which is linked to an activated CDH17-YAP pathway. Additionally, the effectiveness of cisplatin is primarily observed in tumors with relatively high growth rates, highlighting the connection between tumor growth and sensitivity to chemotherapy.
Authors
- Jianhui Tian (ORCID: https://orcid.org/0000-0003-1577-9179)
- Yun Yang
- Yuanyuan Yu (ORCID: https://orcid.org/0000-0003-1276-5695)
- Erxi Wu (ORCID: https://orcid.org/0000-0002-1680-3639)
- Zujun Que (ORCID: https://orcid.org/0000-0001-8739-2489)
- Ge Zhang (ORCID: https://orcid.org/0000-0002-7807-7695)
- Luyao Wang (ORCID: https://orcid.org/0000-0002-9488-4040)
- Jiajun Liu
- Li Yan (ORCID: https://orcid.org/0000-0002-2218-8644)
- Yao Wang (ORCID: https://orcid.org/0000-0002-5296-6312)
- Fangfei Li (ORCID: https://orcid.org/0000-0002-5341-7278)
- Dan Qi (ORCID: https://orcid.org/0009-0001-7002-3908)
Institutions
- Livestrong Foundation (US)
- Hong Kong Baptist University (HK)
- Baylor College of Medicine (US)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Baylor Scott & White Health (US)
- The University of Texas at Austin (US)
- Texas A&M University (US)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1186/s11658-025-00696-9
- Citations
- 6
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- National Natural Science Foundation of China