ASSOCIATION OF HYPERPROLACTINEMIA IN FEMALES WITH INFERTILITY

Introduction: Hyperprolactinemia is an endocrine condition that interferes with ovulation, menstrual periods, and fertility and can affect women. High levels of prolactin inhibit the secretion of gonadotropin and disrupt estrogen levels, which affects the conception rate.Objectives: The objective of this cross-sectional study is to test the relationship between hyperprolactinemia and infertility in women, report hormonal dysfunctions, and analyze factors affecting BMI and thyroid dysfunction in infertile women.Materials and Methods: Cross sectional study was carried out at Khalifa Gul Nawaz Teaching Hospital Bannu, Pakistan and Khyber Teaching Hospital Peshawar, Pakistan. Selected subjects were 100 infertile women with hyperprolactinemia and 50 fertile women. It is based on the blood sampling of patients for the assessment of hormonal levels, BMI, thyroid profile, hormonal studied reproductive history etc. To determine the extent to which hyperprolactinemia was related to infertility, statistical tests were conducted.Results: Infertile women had higher prolactin levels than normal levels (p < 0.001), a higher incidence of irregular menses (72%), and an incidence of subclinical hypothyroidism of 40%. TSH and BMI were also found to be higher than normal values of infertility.Conclusion: Hyperprolactinemia is strongly associated with infertility, based on the disruption of the hormonal balance and metabolic disorders. Prevention, hormone therapy, and changing behavior are crucial to enhance the reproductive success of affected persons.