Adipose Tissue-Derived Exosome Maintains Metabolic Balance of Extracellular Matrix in Rat Nucleus Pulposus Cells
In summary, rat adipose tissue-derived exosomes can increase the levels of Aggrecan, type II collagen, and Bcl2, and decrease the levels of matrix metalloproteinase 3/13, cleaved caspase3, and Bax. Therefore, rat adipose tissue-derived exosomes can maintain metabolic balance of extracellular matrix and protect against apoptosis in rat nucleus pulposus cells.
Authors
- Joan Li
- Sidong Yang (ORCID: https://orcid.org/0000-0003-2342-4714)
- Dalong Yang (ORCID: https://orcid.org/0000-0003-0090-2277)
- Guobin Liu (ORCID: https://orcid.org/0009-0006-3282-1104)
- Ruoyu Zhao
- Sen Liu (ORCID: https://orcid.org/0000-0001-6473-0123)
- Lei Ma (ORCID: https://orcid.org/0000-0003-3976-2566)
Institutions
- Hebei Medical University (CN)
- The University of Queensland (AU)
- Third Hospital of Hebei Medical University (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/ijn.s504649
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61