Locally Delivered Hydrogel with Sustained Release of Flavonol Compound Kaempferol Mitigates Inflammatory Progression of Periodontitis and Enhances the Gut Microflora Composition in Rats
Local treatment with the sustained-release G_K hydrogel composite demonstrates a substantial antiperiodontitis effect in rats by locally attenuating inflammation and is associated with enhancing the microbial composition of intestinal flora, thus aiding in mitigating the inflammatory progression of experimental periodontitis.
Authors
- Xiaoran Xu
- Miaomiao Feng (ORCID: https://orcid.org/0009-0000-4959-7539)
- Yuankun Zhai (ORCID: https://orcid.org/0000-0001-8156-1368)
- Ningli Li (ORCID: https://orcid.org/0000-0001-6734-229X)
- Cory J. Xian (ORCID: https://orcid.org/0000-0002-8467-2845)
- Yonghong Zhang (ORCID: https://orcid.org/0000-0001-8574-9288)
- Yingying Li (ORCID: https://orcid.org/0000-0003-4737-7035)
- Tiejun Li (ORCID: https://orcid.org/0000-0002-2086-1620)
- Mingzhen Yang (ORCID: https://orcid.org/0000-0002-9667-1583)
Institutions
- King University (US)
- University of South Australia (AU)
- Henan University (CN)
- Shanxi Medical University (CN)
- Peking University (CN)
- Second Hospital of Shanxi Medical University (CN)
- Luoyang Orthopedic-Traumatological Hospital of Henan Province (CN)
Publication Details
- Journal
- ACS Biomaterials Science & Engineering
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1021/acsbiomaterials.4c01851
- Citations
- 4
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 6.23
Funders
- Science and Technology Department of Henan Province