Antibacterial effects of lead and tellurium nanoparticles on Proteus - Morganella - Providencia group isolates from Mosul, Iraq

Background: The Proteus- Morganella-Providencia (PMP) Groups exhibit a significant phylogenetic association with Enterobacterales, which sporadically induce pathogenicity in humans. These organisms are classified as opportunistic pathogens, demonstrating a wide distribution across various environmental niches. Constituents of this assemblage possess diverse mechanisms of antibiotic resistance. Objectives: This study evaluated the antibacterial activity of physically synthesized lead (Pb) and tellurium (Te) nanoparticles against Proteus-Morganella-Providencia (PMP) strains.. Method: Three hundred and eighty samples were obtained during the period from March 2023 to September 2023 from different clinical sources. The synthesized tellurium and lead nanoparticles were characterized using UV-visible spectroscopy and FTIR, confirming their functional groups and stability. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) were determined of Te, Pb nanoparticles. Result:The PMP group identified via VITEK 2 automated system . P. mirabilis and . M. morganii were high percentage pathogen from urine. Followed by Providencia stuartii was low percentage from stool and swab sampls. UV-visible spectra of the synthesized nanoparticles recorded a maximum peak at 230nm While FTIR technology showed the presence of functional groups in the nanoparticles used in the study. Results revealed MIC values for PbNPs and TeNPs ranging from 500–2500 μg/ml and MBC values from 1000–3000 μg/ml. PbNPs exhibited superior antimicrobial activity compared to TeNPs, particularly against P. mirabilis P. stuartii, and M. morganii. These findings highlight the potential of Pb and Te nanoparticles as alternative antimicrobials against multidrug-resistant. Conclusion: The physically synthesized Te, Pb nanoparticles were confirmed by UV visible spectroscopy FT-IR, and showed exceptional antimicrobial activity against bacterial strains.