Altered proteomics in brain extracellular vesicles from depressed individuals who died by suicide implicates synaptic processes
To our knowledge, this is the first study to profile EV proteins in depression, providing novel information to better understand the pathophysiology of MDD. This work paves the way for discovering new therapeutic targets for MDD and prompts more investigations into EVs in MDD and other psychiatric disorders.
Authors
- Gustavo Turecki (ORCID: https://orcid.org/0000-0003-4075-2736)
- Pascal Ibrahim
- Lorne Taylor
- Naguib Mechawar (ORCID: https://orcid.org/0000-0003-4960-756X)
- Corina Nagy (ORCID: https://orcid.org/0000-0003-1439-0129)
- Haruka Mitsuhashi
- Jenna Cleyle
Institutions
- Douglas Mental Health University Institute (CA)
- McGill University Health Centre (CA)
- McGill University (CA)
Publication Details
- Journal
- The International Journal of Neuropsychopharmacology
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1093/ijnp/pyaf012
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61