Aortic Valve Calcification Is Induced by the Loss of ALDH1A1 and Can Be Prevented by Agonists of Retinoic Acid Receptor Alpha: Preclinical Evidence for Drug Repositioning
These results show that ALDH1A1 is downregulated in calcified valves, hence promoting VIC transition into an osteoblastic phenotype. Retinoic acid receptor alpha agonists, including all-trans retinoic acid through a drug repositioning strategy, represent a promising and innovative pharmacological approach to prevent calcification of native aortic valves and BPV.
Authors
- Bart Staels (ORCID: https://orcid.org/0000-0002-3784-1503)
- Yoann Sottejeau
- Mickaël Rosa (ORCID: https://orcid.org/0000-0001-6323-3045)
- David M. Smadja (ORCID: https://orcid.org/0000-0001-7731-9202)
- Delphine Corseaux (ORCID: https://orcid.org/0000-0001-8642-1508)
- Thibault Pamart (ORCID: https://orcid.org/0000-0002-8367-4902)
- Éric Van Belle (ORCID: https://orcid.org/0000-0001-6509-443X)
- Francis Juthier
- Jérôme Soquet (ORCID: https://orcid.org/0000-0002-4014-3132)
- Bertrand Vaast
- Mélanie Daniel (ORCID: https://orcid.org/0000-0001-9438-6140)
- Sophie Susen (ORCID: https://orcid.org/0000-0001-5953-163X)
- Johan Abdoul (ORCID: https://orcid.org/0000-0001-5276-5302)
- Frédéric Mouquet
- Flavien Vincent (ORCID: https://orcid.org/0000-0002-1007-1473)
- Alexandre Ung (ORCID: https://orcid.org/0000-0003-1946-4625)
- Jeanne Rancic
- Christina Le Tanno (ORCID: https://orcid.org/0009-0006-6112-7277)
- Annabelle Dupont (ORCID: https://orcid.org/0000-0002-1554-9931)
- Cédric Delhaye
- Ramadan Jashari (ORCID: https://orcid.org/0009-0006-5208-5554)
- Timothée Bigot
- Eloise Borowczac
Institutions
- Valve (United States) (US)
- Inserm (FR)
- Université Paris Cité (FR)
- Université de Lille (FR)
- Institut Pasteur de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Lille’s Cardiology Hospital (FR)
- Sorbonne Paris Cité (FR)
- Institut National de la Transfusion Sanguine (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- National Bank of Belgium (BE)
Publication Details
- Journal
- Circulation
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1161/circulationaha.124.071954
- Citations
- 10
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 13.88