Oxidative Stress Causes Mitochondrial and Electrophysiologic Dysfunction to Promote Atrial Fibrillation in <i> Pitx2 <sup>+/−</sup> </i> Mice
These results demonstrate a critical role for lipid dicarbonyl mediators of oxidative stress in the proarrhythmic remodeling and AF susceptibility that occurs with <i>Pitx2</i> deficiency, implying the possibility of genotype-specific therapy to prevent AF.
Authors
- Joseph C. Van Amburg (ORCID: https://orcid.org/0000-0002-1410-6995)
- Kyungsoo Kim (ORCID: https://orcid.org/0000-0003-2869-0659)
- Matthew B. Murphy (ORCID: https://orcid.org/0000-0002-2297-2703)
- Agnes B. Fogo (ORCID: https://orcid.org/0000-0003-3698-8527)
- Katherine T. Murray (ORCID: https://orcid.org/0000-0002-1342-4457)
- Venkataraman Amarnath (ORCID: https://orcid.org/0000-0001-5766-069X)
- I. Christopher (ORCID: https://orcid.org/0000-0002-0075-094X)
- Vineet Agrawal (ORCID: https://orcid.org/0000-0002-8457-6722)
- Jeffrey E. Saffitz (ORCID: https://orcid.org/0000-0001-8568-9457)
- Joey V. Barnett (ORCID: https://orcid.org/0000-0002-8757-4976)
- Charles D Smart (ORCID: https://orcid.org/0000-0003-0391-3916)
- Zhenjiang Yang (ORCID: https://orcid.org/0000-0002-9315-154X)
- Joyce E. Johnson (ORCID: https://orcid.org/0000-0002-3680-4372)
- Owen P. Dougherty (ORCID: https://orcid.org/0000-0002-9404-0235)
- Kaylen K. Woodall (ORCID: https://orcid.org/0000-0001-7347-9663)
- Tuerdi Subati (ORCID: https://orcid.org/0000-0001-7779-9277)
Institutions
- Beth Israel Deaconess Medical Center (US)
- Vanderbilt University (US)
- Norwegian Womens Public Health Association (NO)
Publication Details
- Journal
- Circulation Arrhythmia and Electrophysiology
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1161/circep.124.013199
- Citations
- 10
- Primary Topic
- Corrosion Behavior and Inhibition
- Type
- article
- Field-Weighted Citation Impact
- 5.18