Neurogenesis and glial impairments in congenital hydrocephalus: insights from a BioGlue-induced fetal lamb model
This study contributed to clarify the profound impact of congenital HCP on neurogenesis and gliogenesis in an experimental fetal lamb model. The VZ disruption and altered expression of key neurogenic and glial markers suggested a significant pathological process underlying neurodevelopmental abnormalities. The findings suggested a potential window for prenatal surgical intervention between E105 and E125 in the sheep model, offering new avenues for prenatal therapeutic approaches and improving surgical outcomes in affected fetuses and neonates.
Authors
- Soner Duru (ORCID: https://orcid.org/0000-0002-3449-4673)
- José L. Peiró (ORCID: https://orcid.org/0000-0002-2272-1381)
- Marc Oria (ORCID: https://orcid.org/0000-0001-9132-9271)
- Kristin Lampe (ORCID: https://orcid.org/0000-0002-7570-2096)
- Francisco M. Sánchez‐Margallo (ORCID: https://orcid.org/0000-0003-2138-988X)
- Dicle Karakaya (ORCID: https://orcid.org/0000-0003-1939-6802)
- Lucas Peiro (ORCID: https://orcid.org/0000-0002-7001-3355)
- Halil Kamil Oge
- José Luis Encinas
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Hospital Universitario La Paz (ES)
- Centro de Cirugía de Mínima Invasión Jesús Usón (ES)
- University of Cincinnati (US)
- Hacettepe University (TR)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1186/s12987-025-00630-3
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Rudi Schulte Research Institute
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
- Instituto de Salud Carlos III