Exploring the Therapeutic Potential of Barbaloin: A Wonder Constituent from Aloe Vera Plant

The aim of current study was to explore chemistry and therapeutic potential of barbaloin. A detailed literature review was carried out at various data bases such as PubMed, Elsevier, Springer, Wiley, Taylor & Francis, etc. The healing plant aloe emodin's main compound is barbaloin (C21H22O9), anthrone's C-glucoside. The Liliace family includes perennial succulent aloe vera. Barbaloin, a pale-yellow aloe vera powder, is a first-group glucoside of the alove emodin anthrone molecule. Barbaloin has anti-inflammatory, cathartic, antiviral, antibacterial, and antioxidant qualities that prevent cancer. Barbaloin also improves cardiovascular health, test perception, enzyme metabolism, and bioavailability. Barbaloin may help treat eczema, psoriasis, and burns. Barbaloin peaked three hours after oral dose. Molecular coupling studies have suggested these drugs may cure COVID-19. Many analytical methods exist for measuring aloin in aloe products. This paper summarizes the pharmacological properties, analytical method, chemical structure, extraction procedure, ethnomedicinal importance, and commercial value of barbaloin, which could be used to develop more effective and accessible formulations.