Higher target attainment for B-lactam antibiotics in patients with Gram-negative bloodstream infections when four times actual minimum inhibitory concentrations and epidemiological cutoff values are applied compared to clinical breakpoints
In our material, higher target attainment rates were seen using targets derived from actual MICs, compared to EUCAST clinical breakpoints. Attaining 100% ƒT > 4MIC was associated with resolution of infection, but the latter finding should be interpreted cautiously.
Authors
- Gustav Torisson (ORCID: https://orcid.org/0000-0001-9012-2068)
- Fredrik Resman (ORCID: https://orcid.org/0000-0002-3433-512X)
- Ilja Areskog Lejbman (ORCID: https://orcid.org/0009-0004-7916-328X)
- Fredrik Sjövall (ORCID: https://orcid.org/0000-0001-5612-0325)
Institutions
- Lund University (SE)
- Skåne University Hospital (SE)
Publication Details
- Journal
- European Journal of Clinical Microbiology & Infectious Diseases
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1007/s10096-025-05068-x
- Citations
- 3
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Lunds Universitet