ActRII or BMPR ligands inhibit skeletal myoblast differentiation, and BMPs promote heterotopic ossification in skeletal muscles in mice
The canonical ActRII ligand-SMAD2/3 and BMP ligand-SMAD1/5 axes can both block human myoblast differentiation. Our observations further demonstrate the osteoinductive function of BMP ligands while pointing to a potential relevancy of blocking the BMP-SMAD1/5 axis in the setting of therapeutic anti-ActRIIA/B inhibition.
Authors
- Kevin Barringer
- Mary Germino (ORCID: https://orcid.org/0000-0001-7523-3798)
- Yasalp Jimenez
- Marc A. Egerman
- Jianing Xu (ORCID: https://orcid.org/0000-0003-2547-4344)
- Maria del Pilar Molina‐Portela
- Corissa McEwen
- David J. Glass (ORCID: https://orcid.org/0000-0001-6187-4164)
- Yu Bai (ORCID: https://orcid.org/0000-0002-0371-8590)
- Romain Donné (ORCID: https://orcid.org/0000-0002-8152-1283)
- Kun Xiong (ORCID: https://orcid.org/0000-0002-3918-9782)
- Abhilash Gadi
- Yuhong Zhang (ORCID: https://orcid.org/0000-0001-5415-1443)
- Tea Shavlakadze
- H. A. Salmon
Institutions
- Regeneron (United States) (US)
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1186/s13395-025-00373-7
- Citations
- 7
- Primary Topic
- Heterotopic Ossification and Related Conditions
- Type
- article
- Field-Weighted Citation Impact
- 11.68
Funders
- Regeneron Pharmaceuticals