DCLK1-mediated regulation of invadopodia dynamics and matrix metalloproteinase trafficking drives invasive progression in head and neck squamous cell carcinoma
This work unveils a novel function of DCLK1 in regulating KIF16B and RAB40B to traffic matrix degrading MMP9 cargo to the distal end of the invadopodia facilitating HNSCC invasion.
Authors
- David R. Johnson (ORCID: https://orcid.org/0000-0003-1094-1341)
- Levi Arnold (ORCID: https://orcid.org/0000-0003-4076-5772)
- Michael P. Washburn (ORCID: https://orcid.org/0000-0001-7568-2585)
- Shrikant Anant (ORCID: https://orcid.org/0000-0003-4193-3053)
- Thuc Ly (ORCID: https://orcid.org/0000-0002-3971-5404)
- Michael J. Barry (ORCID: https://orcid.org/0000-0001-6508-7109)
- Nanda Kumar Yellapu (ORCID: https://orcid.org/0000-0002-3095-6375)
- Linheng Li (ORCID: https://orcid.org/0000-0001-9963-430X)
- Pachiappan Arjunan (ORCID: https://orcid.org/0000-0001-9470-1171)
- David Standing (ORCID: https://orcid.org/0000-0003-3153-4374)
- Avisha Pandey
- Nathan Farrokhian (ORCID: https://orcid.org/0000-0001-8731-4464)
- Sufi M. Thomas (ORCID: https://orcid.org/0000-0001-5370-0842)
- Austin Morrison (ORCID: https://orcid.org/0000-0002-6253-9605)
- Laura Jackson (ORCID: https://orcid.org/0009-0001-3601-7862)
- Shahid Umar (ORCID: https://orcid.org/0000-0003-0579-6813)
- Marrion Yap (ORCID: https://orcid.org/0009-0003-3100-1428)
- Juan Povedano Gomez
- Angela Kaczorowski-Worthley
- Carter Tews
Institutions
- Stowers Institute for Medical Research (US)
- University of Kansas (US)
- The University of Kansas Cancer Center (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1186/s12943-025-02264-3
- Citations
- 5
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.68