Analgesic therapy failure in a COMT HPS/HPS diplotype carrier heterozygous for the CYP2D6 *4 allele with fibromyalgia—a case report

We hypothesize that the broad TF of pain medications and associated high pain sensitivity could be related to the patient's genetic predisposition in CYP2D6 and COMT, warranting further investigation in a larger patient sample.

Authors

Samuel Allemann (ORCID: https://orcid.org/0000-0003-4067-9401)
Trudi Schüpbach
Anna Bollinger (ORCID: https://orcid.org/0000-0003-4616-2534)
Henriette E. Meyer zu Schwabedissen (ORCID: https://orcid.org/0000-0003-0458-4579)
Céline K. Stäuble (ORCID: https://orcid.org/0000-0002-2437-4803)
Julia Gianora

Institutions

University of Basel (CH)
Solothurner Spitäler (CH)

Publication Details

Journal: PAIN Reports
Published: 2025-02-21
DOI: https://doi.org/10.1097/pr9.0000000000001248
Citations: 1
Primary Topic: Pain Management and Placebo Effect
Type: article
Field-Weighted Citation Impact: 1.43

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article

Analgesic therapy failure in a COMT HPS/HPS diplotype carrier heterozygous for the CYP2D6 *4 allele with fibromyalgia—a case report

Samuel Allemann, Trudi Schüpbach, Anna Bollinger, Henriette E. Meyer zu Schwabedissen et al.

Feb 21, 2025

1 citations

PAIN Reports

Pain Management and Placebo Effect

1.43

article

Analgesic therapy failure in a COMT HPS/HPS diplotype carrier heterozygous for the CYP2D6 *4 allele with fibromyalgia—a case report

Samuel Allemann, Trudi Schüpbach, Anna Bollinger, Henriette E. Meyer zu Schwabedissen, Céline K. Stäuble, Julia Gianora

February 21, 2025article en

1 citations

Abstract

We hypothesize that the broad TF of pain medications and associated high pain sensitivity could be related to the patient's genetic predisposition in CYP2D6 and COMT, warranting further investigation in a larger patient sample.

PAIN ReportsVol. 10(2)

University of Basel (CH), Solothurner Spitäler (CH)

Good health and well-being

Openalex Percentile: Top 22%

Pain Management and Placebo Effect

1.43

DOI Open Access PDF OpenAlex

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