Investigating the epigenetic landscape of symptomatic disk degeneration: a case study
This case study provides a promising list of candidate genes for therapeutic development for discogenic LBP and suggests a role for DNA methylation in the development of symptomatic vs asymptomatic IVD degeneration, calling for further research to validate and expand these findings.
Authors
- Kumar G. Belani (ORCID: https://orcid.org/0000-0003-1784-136X)
- Laura S. Stone (ORCID: https://orcid.org/0000-0002-7015-2101)
- Yuya Kawarai (ORCID: https://orcid.org/0000-0002-3321-9389)
- Dmitriy Sheyn (ORCID: https://orcid.org/0000-0002-3333-1485)
- Taylor D. Yeater (ORCID: https://orcid.org/0000-0002-9078-3066)
- Seunghwan Lee (ORCID: https://orcid.org/0000-0003-4158-5714)
- Manuel R. Pinto (ORCID: https://orcid.org/0000-0003-1451-331X)
- David S. Beebe
Institutions
- Cedars-Sinai Medical Center (US)
- University of Minnesota (US)
- Chiba University (JP)
- Twin Cities Spine Center (US)
Publication Details
- Journal
- PAIN Reports
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1097/pr9.0000000000001237
- Citations
- 1
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Institute on Drug Abuse
- National Institute of Neurological Disorders and Stroke