Ultrasound-responsive and biodegradable BTO/PLLA piezoelectric films for wireless neurostimulation

Precise control of neural activity is essential for the effective treatment of neurological disorders. This research presents an ultrasound-responsive, biodegradable piezoelectric neurostimulator using Poly(L-lactic acid) (PLLA) combined with barium titanate (BTO) nanoparticles. PLLA's biodegradability and piezoelectric properties make it ideal for energy harvesting in implantable devices, enabling wireless, self-powered stimulation. When exposed to external ultrasonic waves, the device converts mechanical energy into electrical energy through the piezoelectric effect, delivering targeted electrical stimulation. The stimulator gradually degrades within the body after use, eliminating the need for secondary removal surgery. Integrated with a signal processing module, the device can provide tailored stimulation protocols based on clinical requirements. This novel, biodegradable system offers a promising solution for long-term, sustainable neural stimulation.