Engineered Methioninase-expressing Tumor-targeting<i>Salmonella typhimurium</i>A1-R Inhibits Syngeneic-Cancer Mouse Models by Depleting Tumor Methionine
Tumor-targeting <i>Salmonella typhimurium</i> A1-R engineered to express the <i>Pseudomonas putida methioninase</i> gene, inhibited LLC tumor growth in a syngeneic mouse model and reduced the methionine level in the tumor. <i>Salmonella typhimurium</i> A1-R-rMETase combines the tumor targeting and killing capability of <i>Salmonella typhimurium</i> A1-R plus rMETase which targets the methionine addiction of cancer.
Authors
- Takuya Tsunoda (ORCID: https://orcid.org/0000-0002-6416-8211)
- Yutaro Kubota (ORCID: https://orcid.org/0000-0002-2917-8764)
- Michael Bouvet (ORCID: https://orcid.org/0000-0002-0086-2159)
- Ming Zhao (ORCID: https://orcid.org/0000-0001-5971-7303)
- Koichi Kubota
- MOTOKAZU SATO
- Koya Obara (ORCID: https://orcid.org/0000-0002-5235-3161)
- KOHEI MIZUTA
- NORIYUKI MASAKI (ORCID: https://orcid.org/0000-0002-0463-9608)
- Sei Morinaga (ORCID: https://orcid.org/0000-0003-2961-9432)
- YUSUKE AOKI (ORCID: https://orcid.org/0000-0002-1701-9678)
- Robert M. Hoffman
- Qinghong Han
Institutions
- SHOWA Medical University (JP)
- University of California San Diego (US)
- AntiCancer (United States) (US)
- Kitasato University (JP)
Publication Details
- Journal
- Cancer Genomics & Proteomics
- Published
- 2025-02-24
- DOI
- https://doi.org/10.21873/cgp.20499
- Citations
- 2
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.47