Optogenetic inhibition of ventrolateral orbitofrontal cortex astrocytes facilitates ventrolateral periaqueductal gray glutamatergic activity to reduce hypersensitivity in infraorbital nerve injury rat model
These findings suggest that the astrocytic subpopulation in the vlOFC and its robust influence on vlPAG glutamatergic neurons play a crucial role in restoring descending pain processing pathways, potentially contributing to the development of novel therapeutic approaches for TNP management.
Authors
- Elina KC (ORCID: https://orcid.org/0000-0001-5039-2733)
- Muhammad Ali (ORCID: https://orcid.org/0000-0002-5861-1993)
- Young Seok Park (ORCID: https://orcid.org/0000-0001-7685-6292)
- Hyong Kyu Kim (ORCID: https://orcid.org/0000-0001-7247-1627)
- Jaisan Islam (ORCID: https://orcid.org/0000-0001-5416-8608)
- Md Taufiqur Rahman (ORCID: https://orcid.org/0009-0004-9694-6972)
Institutions
- Chungbuk National University (KR)
- Augusta University (US)
- Chungbuk National University Hospital (KR)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1186/s10194-025-01977-6
- Citations
- 7
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 9.23
Funders
- National Research Foundation of Korea