Clinical Behavior of Breast Cancer in Young <i>BRCA</i> Carriers and Prediagnostic Awareness of Germline <i>BRCA</i> Status

This global study provides evidence on the different clinical behavior of breast cancer in young <i>BRCA1</i> and <i>BRCA2</i> carriers. Identifying a <i>BRCA</i> PV in healthy individuals was associated with earlier-stage breast cancer diagnosis and lower treatment burden, as well as better unadjusted OS.

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Publication Details

Journal
Journal of Clinical Oncology
Published
2025-02-24
DOI
https://doi.org/10.1200/jco-24-01334
Citations
14
Primary Topic
BRCA gene mutations in cancer
Type
article
Field-Weighted Citation Impact
25.44
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article

Clinical Behavior of Breast Cancer in Young BRCA Carriers and Prediagnostic Awareness of Germline BRCA Status

Carmen Criscitiello, Shani Paluch–Shimon, Anne‐Sophie Hamy, Halle C. F. Moore et al.
14 citations
Journal of Clinical Oncology
BRCA gene mutations in cancer
25.44
article

Clinical Behavior of Breast Cancer in Young BRCA Carriers and Prediagnostic Awareness of Germline BRCA Status

Carmen Criscitiello, Shani Paluch–Shimon, Anne‐Sophie Hamy, Halle C. F. Moore, Hee Jeong Kim, Angela Toss, Fabio Puglisi, Stephanie M. Wong, Claudio Vernieri, Katarzyna Pogoda, Luca Livraghi, Laura De Marchis, Eva Blondeaux, Alberta Ferrari, Kathryn J. Ruddy, François P. Duhoux, Cynthia Villarreal‐Garza, Ann H. Partridge, Kelly‐Anne Phillips, Alexios Matikas, Kenny A. Rodriguez‐Wallberg, Hans Wildiers, Maria Alice Franzoi, Marco Bruzzone, Christine Rousset‐Jablonski, Florentine Hilbers, Robert Fruscio, Michail Ignatiadis, Wanyuan Cui, Tiphaine Renaud, Mariya Rozenblit, Luca Boni, Maria Vittoria Dieci, Elisa Agostinetto, Matteo Lambertini, Judith Balmañà, Rinat Bernstein‐Molho, Jyoti Bajpai, Loredana Maria Tomasello
article en
14 citations

Abstract

This global study provides evidence on the different clinical behavior of breast cancer in young <i>BRCA1</i> and <i>BRCA2</i> carriers. Identifying a <i>BRCA</i> PV in healthy individuals was associated with earlier-stage breast cancer diagnosis and lower treatment burden, as well as better unadjusted OS.

Journal of Clinical OncologyVol. 43(14)
Université Claude Bernard Lyon 1 (FR), Ulsan College (KR), University of Modena and Reggio Emilia (IT), University of Udine (IT), Cliniques Universitaires Saint-Luc (BE), Cleveland Clinic (US), Université Libre de Bruxelles (BE), Mayo Clinic (US), Karolinska University Hospital (SE), University of Padua (IT), Inserm (FR), Tel Aviv University (IL), The University of Melbourne (AU), University of Milan (IT), Hebrew University of Jerusalem (IL), Homi Bhabha National Institute (IN), Université Paris Cité (FR), University of Pavia (IT), Sheba Medical Center (IL), Tata Memorial Hospital (IN), Policlinico Umberto I (IT), Peter MacCallum Cancer Centre (AU), Asan Medical Center (KR), Jewish General Hospital (CA), Institut Jules Bordet (BE), Karolinska Institutet (SE), The Netherlands Cancer Institute (NL), Jerusalem Multidisciplinary College (IL), University of Ulsan (KR), Hospital Zambrano Hellion (MX), Azienda Ospedaliero-Universitaria di Modena (IT), Istituto Oncologico Veneto (IT), Azienda Ospedaliera San Gerardo (IT), Dana-Farber Cancer Institute (US), Health Services and Performance Research Laboratory (FR), Centre de Recherche en Cancérologie de Lyon (FR), Vall d'Hebron Hospital Universitari (ES), Centro di Riferimento Oncologico (IT), Institut Bergonié (FR), Ospedale Policlinico San Martino (IT), The Maria Sklodowska-Curie National Research Institute of Oncology (PL), Policlinico San Matteo Fondazione (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Fondazione IRCCS Istituto Nazionale dei Tumori (IT), Smilow Cancer Hospital (US), Hospital of Prato (IT), Vall d'Hebron Institute of Oncology (ES), Research on healthcare performance (FR), McGill University (CA), European Institute of Oncology (IT), University of Milano-Bicocca (IT), Institut Curie (FR), University of Genoa (IT), Sapienza University of Rome (IT), University of Palermo (IT), Tecnológico de Monterrey (MX), KU Leuven (BE)
Good health and well-being
Openalex Percentile: Top 0%
BRCA gene mutations in cancer
25.44
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