Clinical Behavior of Breast Cancer in Young <i>BRCA</i> Carriers and Prediagnostic Awareness of Germline <i>BRCA</i> Status
This global study provides evidence on the different clinical behavior of breast cancer in young <i>BRCA1</i> and <i>BRCA2</i> carriers. Identifying a <i>BRCA</i> PV in healthy individuals was associated with earlier-stage breast cancer diagnosis and lower treatment burden, as well as better unadjusted OS.
Authors
- Carmen Criscitiello (ORCID: https://orcid.org/0000-0001-9064-0113)
- Shani Paluch–Shimon (ORCID: https://orcid.org/0000-0002-6677-2199)
- Anne‐Sophie Hamy (ORCID: https://orcid.org/0000-0003-4430-3022)
- Halle C. F. Moore (ORCID: https://orcid.org/0000-0002-7472-9350)
- Hee Jeong Kim
- Angela Toss (ORCID: https://orcid.org/0000-0002-1854-6701)
- Fabio Puglisi (ORCID: https://orcid.org/0000-0003-0573-4938)
- Stephanie M. Wong (ORCID: https://orcid.org/0000-0002-6850-2192)
- Claudio Vernieri (ORCID: https://orcid.org/0000-0003-1577-8176)
- Katarzyna Pogoda (ORCID: https://orcid.org/0000-0002-9902-711X)
- Luca Livraghi (ORCID: https://orcid.org/0000-0002-9119-6277)
- Laura De Marchis (ORCID: https://orcid.org/0000-0003-2195-7955)
- Eva Blondeaux (ORCID: https://orcid.org/0000-0001-9566-4579)
- Alberta Ferrari (ORCID: https://orcid.org/0000-0003-2525-3787)
- Kathryn J. Ruddy (ORCID: https://orcid.org/0000-0001-6298-332X)
- François P. Duhoux (ORCID: https://orcid.org/0000-0002-5429-7888)
- Cynthia Villarreal‐Garza (ORCID: https://orcid.org/0000-0003-3587-339X)
- Ann H. Partridge (ORCID: https://orcid.org/0000-0002-4722-4824)
- Kelly‐Anne Phillips (ORCID: https://orcid.org/0000-0002-0475-1771)
- Alexios Matikas (ORCID: https://orcid.org/0000-0002-4122-9624)
- Kenny A. Rodriguez‐Wallberg (ORCID: https://orcid.org/0000-0003-4378-6181)
- Hans Wildiers (ORCID: https://orcid.org/0000-0001-8990-7837)
- Maria Alice Franzoi (ORCID: https://orcid.org/0000-0002-2470-6054)
- Marco Bruzzone (ORCID: https://orcid.org/0000-0002-8821-4542)
- Christine Rousset‐Jablonski (ORCID: https://orcid.org/0000-0001-7087-5687)
- Florentine Hilbers (ORCID: https://orcid.org/0000-0002-6764-3102)
- Robert Fruscio (ORCID: https://orcid.org/0000-0001-5688-2194)
- Michail Ignatiadis (ORCID: https://orcid.org/0000-0002-4493-3748)
- Wanyuan Cui (ORCID: https://orcid.org/0000-0002-5077-6814)
- Tiphaine Renaud
- Mariya Rozenblit (ORCID: https://orcid.org/0000-0003-0244-429X)
- Luca Boni (ORCID: https://orcid.org/0000-0003-2217-4047)
- Maria Vittoria Dieci (ORCID: https://orcid.org/0000-0002-3967-9861)
- Elisa Agostinetto (ORCID: https://orcid.org/0000-0003-0295-7511)
- Matteo Lambertini (ORCID: https://orcid.org/0000-0003-1797-5296)
- Judith Balmañà (ORCID: https://orcid.org/0000-0002-0762-6415)
- Rinat Bernstein‐Molho (ORCID: https://orcid.org/0000-0002-4068-9514)
- Jyoti Bajpai (ORCID: https://orcid.org/0000-0001-7657-3460)
- Loredana Maria Tomasello
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Ulsan College (KR)
- University of Modena and Reggio Emilia (IT)
- University of Udine (IT)
- Cliniques Universitaires Saint-Luc (BE)
- Cleveland Clinic (US)
- Université Libre de Bruxelles (BE)
- Mayo Clinic (US)
- Karolinska University Hospital (SE)
- University of Padua (IT)
- Inserm (FR)
- Tel Aviv University (IL)
- The University of Melbourne (AU)
- University of Milan (IT)
- Hebrew University of Jerusalem (IL)
- Homi Bhabha National Institute (IN)
- Université Paris Cité (FR)
- University of Pavia (IT)
- Sheba Medical Center (IL)
- Tata Memorial Hospital (IN)
- Policlinico Umberto I (IT)
- Peter MacCallum Cancer Centre (AU)
- Asan Medical Center (KR)
- Jewish General Hospital (CA)
- Institut Jules Bordet (BE)
- Karolinska Institutet (SE)
- The Netherlands Cancer Institute (NL)
- Jerusalem Multidisciplinary College (IL)
- University of Ulsan (KR)
- Hospital Zambrano Hellion (MX)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- Istituto Oncologico Veneto (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Dana-Farber Cancer Institute (US)
- Health Services and Performance Research Laboratory (FR)
- Centre de Recherche en Cancérologie de Lyon (FR)
- Vall d'Hebron Hospital Universitari (ES)
- Centro di Riferimento Oncologico (IT)
- Institut Bergonié (FR)
- Ospedale Policlinico San Martino (IT)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Smilow Cancer Hospital (US)
- Hospital of Prato (IT)
- Vall d'Hebron Institute of Oncology (ES)
- Research on healthcare performance (FR)
- McGill University (CA)
- European Institute of Oncology (IT)
- University of Milano-Bicocca (IT)
- Institut Curie (FR)
- University of Genoa (IT)
- Sapienza University of Rome (IT)
- University of Palermo (IT)
- Tecnológico de Monterrey (MX)
- KU Leuven (BE)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1200/jco-24-01334
- Citations
- 14
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 25.44