Feasibility and acceptability of remote APOE-genotyping among research volunteers of an online recruitment registry (The Dutch Brain Research Registry)
Our results suggest that APOE-ɛ4 genotyping in participants of an online research registry is feasible, well received and could be used to prescreen individuals at risk for AD for prevention studies. Adding a positive family history before invitation for APOE-genotyping, would further improve the prescreening process and reduce screen failures when identifying carriers.
Authors
- Leonie N.C. Visser (ORCID: https://orcid.org/0000-0003-3487-7938)
- Wiesje M. van der Flier (ORCID: https://orcid.org/0000-0001-8766-6224)
- Dionne M. Nijland
- Lisa Waterink (ORCID: https://orcid.org/0009-0002-5469-4098)
- Sven J. van der Lee (ORCID: https://orcid.org/0000-0003-1606-8643)
- Sietske A.M. Sikkes (ORCID: https://orcid.org/0000-0002-0161-3656)
- Marissa D. Zwan (ORCID: https://orcid.org/0000-0003-0879-2164)
- Yolande A.L. Pijnenburg (ORCID: https://orcid.org/0000-0003-2464-1905)
- F I van der Zee
Institutions
- Amsterdam Neuroscience (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1016/j.tjpad.2025.100099
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- EU Joint Programme – Neurodegenerative Disease Research
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Hersenstichting
- Alzheimer Nederland
- Amsterdam Neuroscience