Association of ABCB1 C1236T Gene Polymorphisms With the Postoperative Analgesic Effects of Sufentanil and Morphine in Patients With Femoral Fractures

The ABCB1 C1236T gene polymorphism was a genetic factor influencing early postoperative pain in Han patients with FFs. However, epidural administration of morphine could mitigate the impact of this gene mutation on early analgesia induced by sufentanil.

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Publication Details

Journal
Journal of PeriAnesthesia Nursing
Published
2025-02-24
DOI
https://doi.org/10.1016/j.jopan.2024.10.017
Primary Topic
Anesthesia and Pain Management
Type
article
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article

Association of ABCB1 C1236T Gene Polymorphisms With the Postoperative Analgesic Effects of Sufentanil and Morphine in Patients With Femoral Fractures

Jianzhong An, Chen Wang, Shigang Qiao, Qianli Huang et al.
Journal of PeriAnesthesia Nursing
Anesthesia and Pain Management
article

Association of ABCB1 C1236T Gene Polymorphisms With the Postoperative Analgesic Effects of Sufentanil and Morphine in Patients With Femoral Fractures

Jianzhong An, Chen Wang, Shigang Qiao, Qianli Huang, Fuqi Xu, Xiaofeng Qin
article en

Abstract

The ABCB1 C1236T gene polymorphism was a genetic factor influencing early postoperative pain in Han patients with FFs. However, epidural administration of morphine could mitigate the impact of this gene mutation on early analgesia induced by sufentanil.

Journal of PeriAnesthesia NursingVol. 40(4)
Shanghai University of Traditional Chinese Medicine (CN), Suzhou Municipal Hospital (CN), Traditional Chinese Medicine Hospital of Kunshan (CN), Nanjing University (CN)
Zero hunger
Openalex Percentile: Top 94%
Anesthesia and Pain Management
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