Melatonin for preventing postoperative delirium in elderly patients: A multicenter randomized placebo-controlled pilot study
Based on our observations, a sample size of >1000 patients is required for a definitive trial to evaluate the role of melatonin in reducing the incidence of POD. Design changes need to be considered to address feasibility challenges and ongoing post-pandemic modifications to patient care.
Authors
- Maram Khaled (ORCID: https://orcid.org/0000-0003-1200-1388)
- John Agzarian (ORCID: https://orcid.org/0000-0002-6553-1262)
- Jason Chui (ORCID: https://orcid.org/0000-0001-8415-6149)
- Maria F. Gomez (ORCID: https://orcid.org/0000-0001-6210-3142)
- Yaron Shargall (ORCID: https://orcid.org/0000-0001-8585-0327)
- Harsha Shanthanna (ORCID: https://orcid.org/0000-0002-4105-4465)
- Nawar A. Alkhamesi (ORCID: https://orcid.org/0000-0001-6217-6253)
- Joycelyne Ewusie (ORCID: https://orcid.org/0000-0003-4292-1134)
- James Paul (ORCID: https://orcid.org/0000-0002-7437-3868)
- Bobby Shayegan (ORCID: https://orcid.org/0000-0001-9570-610X)
- Jessica Bogach
- Lehana Thabane (ORCID: https://orcid.org/0009-0004-9034-0021)
Institutions
- Western University (CA)
- Population Health Research Institute (CA)
- St. Joseph's Hospital (CA)
- St Joseph's Health Care (CA)
- St. Joseph's Hospital (US)
- Impact (CA)
- St. Joseph’s Healthcare Hamilton (CA)
- McMaster University (CA)
Publication Details
- Journal
- Medicine
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1097/md.0000000000041615
- Citations
- 3
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.64