ITIH5-mediated fibroblast/macrophage crosstalk exacerbates cardiac remodelling after myocardial infarction
ITIH5 could be used as a diagnostic marker for ICM. Moreover, ITIH5 expression was upregulated after MI, which accelerated ECM-fibroblast-macrophage interaction, thereby promoting macrophage profibrotic phenotype transformation, CFs activation, and cardiac fibrotic remodelling.
Authors
- Miaofu Li
- Liuying Chen
- Siyao Zhan
- Jiamin Huang
- Huimin Chen (ORCID: https://orcid.org/0009-0004-2677-2794)
- Meng Li (ORCID: https://orcid.org/0000-0002-8000-3003)
- Hao Chen (ORCID: https://orcid.org/0000-0002-9943-9237)
- Yizhou Xu (ORCID: https://orcid.org/0000-0002-0527-5615)
- Xuechun Chen
- Yigang Zhong (ORCID: https://orcid.org/0000-0002-6996-3716)
- Xiaofei Gao (ORCID: https://orcid.org/0000-0001-7428-119X)
- Linhao Xu (ORCID: https://orcid.org/0000-0003-1275-665X)
- Yirong Wu
Institutions
- Zhejiang Chinese Medical University (CN)
- Westlake University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1186/s12967-025-06244-5
- Citations
- 5
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 6.94
Funders
- Medical Science and Technology Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province