Comparative Efficacy of Pre and Post-Exposure Pro-Phylaxis Using Local Rabies Vaccine by IM Route

Rabies is an infectious but preventable disease with proper vaccination. Pre-exposure prophylaxis means using medications or vaccines against a given pathogen in people who have not yet been exposed to the given pathogen. Post-exposure prophylaxis means the use of medications in people who are exposed to a certain pathogen. This study aimed to evaluate the seroconversion of anti-rabies IgG antibodies following the administration of the Indigenous rabies vaccine. For this purpose, n=150 individuals were enrolled with 20% in the pre-exposure prophylaxis group (PrEPG) and 80% in the post-exposure prophylaxis group (PEPG). The PEPG is further categorized into 3 different sub-groups [(2-15), (15-45), (>45) years] according to their ages. Indirect ELISA was used for the detection of antibodies IgG in serum samples. Seroconversion level revealed that the local vaccine used is effective in inducing immunity in individuals with OD values ranging from 0.76-≥2.92 about positive control OD values.