Splicing factor RBM10 loss fuels thyroid cancer metastasis
In this issue of JEM, Krishnamoorthy et al. (https://doi.org/10.1084/jem.20241029) identify the loss of the splicing factor RBM10 as a driver of metastasis in thyroid cancer through the regulation of RNA splicing. The synthetic lethal interaction between NF-κB and RBM10 loss reveals a potential therapeutic vulnerability.
Authors
- Ledong Wan (ORCID: https://orcid.org/0000-0002-2450-3986)
- Kevin Coughlin
Institutions
- State University of New York (US)
- Stony Brook School (US)
- Stony Brook University (US)
Publication Details
- Journal
- The Journal of Experimental Medicine
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1084/jem.20250050
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Cancer Society
- Stony Brook University