Untargeted Tear Proteomics in a Large South-Asian Cohort Reveals Inflammatory Signaling, ECM Remodeling, and Altered Metabolism in Keratoconus
Our data unveiled novel tear fluid proteins involved in unique biological processes such as neutrophil degranulation, autophagy, metabolic alterations, protein phosphorylation, and more, apart from the ECM modulation and inflammatory pathways. Although the newly identified progressive KC biomarkers will help in disease characterization, identified molecular pathways may serve as novel therapeutic targets.
Authors
- Krishnatej Nishtala (ORCID: https://orcid.org/0000-0001-8410-9553)
- Vrushali Deshpande (ORCID: https://orcid.org/0000-0001-6758-6091)
- Marlies Gijs (ORCID: https://orcid.org/0000-0002-7203-0159)
- Trailokyanath Panigrahi
- Rudy M.M.A. Nuijts (ORCID: https://orcid.org/0000-0003-2218-9660)
- Ramaraj Kannan (ORCID: https://orcid.org/0009-0005-9334-8747)
- Arkasubhra Ghosh (ORCID: https://orcid.org/0000-0002-6570-5891)
- Lei Zhou (ORCID: https://orcid.org/0000-0001-5893-6002)
- Siew Kwan Koh
- Pooja Khamar
- Rohit Shetty
Institutions
- Hong Kong Polytechnic University (HK)
- Maastricht University (NL)
- Singapore Eye Research Institute (SG)
- Narayana Nethralaya (IN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1167/iovs.66.2.60
- Citations
- 7
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 9.52