A Brain-Targeting NIR-II Polymeric Phototheranostic Nanoplatform toward Orthotopic Drug-Resistant Glioblastoma
Glioblastoma is the most common and devastating brain tumor owing to its high invasiveness and high-frequency drug resistance. Near infrared-II (NIR-II) imaging-guided phototherapy based on polymer luminogens provides a promising remedy against drug-resistant glioma, but it is difficult to maximize photoenergy utilization. Herein, we designed a series of semiconducting polymers to boost the visualization and ablation of glioblastoma. By subtly engineering the side chains or substituents on the phenothiazine and thiophene moieties, an NIR-II polymer luminogen with high-quality fluorescence performance, good solubility, superior photothermal conversion, and balanced reactive oxygen species generation is achieved. The optimal polymer possesses a branched alkyl chain and tetraphenylethylene pendant to manipulate the equilibrium between the radiative and nonradiative energy-dissipating channels. High-sensitivity NIR-II imaging was used to monitor the blood-brain barrier penetration and glioma cell targeting of apolipoprotein E-modified polymer nanoparticles. The NIR irradiation triggers and maximizes the photon utilization in prominent photodynamic/photothermal synergistic therapy in orthotopic drug-resistant glioblastoma.
Authors
- Ting Han (ORCID: https://orcid.org/0000-0001-7850-1313)
- Jincheng Guo (ORCID: https://orcid.org/0000-0002-7430-7836)
- Bingyang Shi (ORCID: https://orcid.org/0000-0002-1043-3163)
- Yong Zhong (ORCID: https://orcid.org/0000-0003-1446-3148)
- Ping Shangguan
- Danmin Lin
- Yi‐Sheng Liu (ORCID: https://orcid.org/0000-0002-1085-1947)
- Gaoyang Wang (ORCID: https://orcid.org/0009-0007-1595-659X)
- Xiang Su (ORCID: https://orcid.org/0000-0002-6346-7666)
- Ben Zhong Tang (ORCID: https://orcid.org/0000-0002-0293-964X)
- Dong Wang (ORCID: https://orcid.org/0000-0001-5137-0771)
- Li Xi (ORCID: https://orcid.org/0000-0003-0311-8197)
- Jiefei Wang (ORCID: https://orcid.org/0000-0001-8374-8847)
- Junkai Liu (ORCID: https://orcid.org/0000-0001-5023-0822)
- Zhengqun Luo
- Cai Qi
Institutions
- Target (United States) (US)
- Guangdong University of Technology (CN)
- Shenzhen Institute of Information Technology (CN)
- Henan University (CN)
- Shenzhen University (CN)
- Hong Kong University of Science and Technology (HK)
- Henan University Huaihe Hospital and Huaihe Clinical Institute (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Division of Materials Science and Engineering (AU)
- Macquarie University (AU)
Publication Details
- Journal
- Nano Letters
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1021/acs.nanolett.4c05470
- Citations
- 19
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 12.81
Funders
- National Natural Science Foundation of China
- Shenzhen University
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Australian Research Council
- Henan Provincial Science and Technology Research Project
- Science and Technology Innovation Talents in Universities of Henan Province
- Basic and Applied Basic Research Foundation of Guangdong Province