Plasmin cleavage of β2-glycoprotein I alters its structure and ability to bind to pathogenic antibodies
Cleavage of β2GPI by plasmin results in the production of a unique S-shaped structural conformation and higher patient antibody binding. This novel structure may increase the production of antibodies and explain the loss of binding to phospholipids described previously for plasmin-clipped β2GPI.
Authors
- Paul A. Dalby (ORCID: https://orcid.org/0000-0002-0980-8167)
- Hannah M. Britt
- Thomas McDonnell (ORCID: https://orcid.org/0000-0002-1712-9957)
- Christophe J. Lalaurie
- Konstantinos Thalassinos (ORCID: https://orcid.org/0000-0001-5072-8428)
- Anisur Rahman (ORCID: https://orcid.org/0000-0003-2346-4484)
- Ian Giles (ORCID: https://orcid.org/0000-0001-8913-3894)
- Hannah F. Bradford (ORCID: https://orcid.org/0000-0002-6827-3190)
- Mihaela Delcea (ORCID: https://orcid.org/0000-0002-0851-9072)
- Stephen J. Perkins (ORCID: https://orcid.org/0000-0001-9218-9805)
- Xin Gao (ORCID: https://orcid.org/0000-0003-0877-0643)
- Jayesh Gor (ORCID: https://orcid.org/0000-0002-1654-1392)
- Charis Pericleous (ORCID: https://orcid.org/0000-0001-8804-0493)
Institutions
- Biochemical Society (GB)
- The Royal Free Hospital (GB)
- Universität Greifswald (DE)
- Institute of Structural and Molecular Biology (GB)
- Institute of Infection and Immunity (CA)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1016/j.jtha.2025.02.015
- Citations
- 3
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Wellcome Trust
- Versus Arthritis
- Engineering and Physical Sciences Research Council
- Medical Research Foundation