Global MicroRNA Profiling of HSV-1 Infected Cornea Identifies miR-329 as a Novel Regulator of Virus Infection
Our findings suggest that miR-329 functions as a pro-viral miRNA by disrupting TLR9 signaling, thus facilitating HSV-1 replication. Inhibition of miR-329 enhances TLR9-mediated antiviral responses, highlighting the potential of targeting host miRNAs as a novel therapeutic strategy for managing viral keratitis.
Authors
- Hemant P. Borase (ORCID: https://orcid.org/0000-0003-2097-1018)
- Araceli Valverde (ORCID: https://orcid.org/0000-0001-6044-0209)
- Divya Kapoor (ORCID: https://orcid.org/0000-0001-7142-3025)
- Kristelle J. Capistrano (ORCID: https://orcid.org/0000-0003-4349-9924)
- Tejabhiram Yadavalli (ORCID: https://orcid.org/0000-0001-8584-2685)
- Pankaj Sharma (ORCID: https://orcid.org/0000-0002-4996-3946)
- Deepak Shukla (ORCID: https://orcid.org/0000-0002-3039-6953)
- Raza Ali Naqvi (ORCID: https://orcid.org/0000-0003-0187-2081)
- Afsar Raza Naqvi (ORCID: https://orcid.org/0000-0001-7436-3056)
Institutions
- University of Illinois Chicago (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1167/iovs.66.2.61
- Citations
- 4
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.75