Synergistic Effects of Transarterial Chemoembolization and Lenvatinib on HIF-1α Ubiquitination and Prognosis Improvement in Hepatocellular Carcinoma
The combination of lenvatinib and TACE significantly improved survival in patients with HCC. The mechanistic foundation seems to be the lenvatinib-triggered degradation of HIF-1α via the mouse double minute 2 homolog-dependent ubiquitination pathway, highlighting a potential therapeutic target in HCC treatment.
Authors
- Han Chu Lee (ORCID: https://orcid.org/0000-0002-7631-4124)
- Jonggi Choi (ORCID: https://orcid.org/0000-0002-7470-5850)
- Danbi Lee (ORCID: https://orcid.org/0000-0002-8336-0006)
- Ju Hyun Shim (ORCID: https://orcid.org/0000-0002-7336-1371)
- Won‐Mook Choi (ORCID: https://orcid.org/0000-0002-9158-1765)
- Young‐Suk Lim (ORCID: https://orcid.org/0000-0002-1544-577X)
- Sung Won Chung (ORCID: https://orcid.org/0000-0001-7263-6866)
- Kang Mo Kim (ORCID: https://orcid.org/0000-0002-3180-3178)
- Jin Sun Kim
Institutions
- Ulsan College (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1228
- Citations
- 5
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.61