Toxoplasma gondii ROP18 induces maternal–fetal dysfunction by downregulating CD73 expression on decidual macrophages
TgROP18 can significantly reduce CD73 expression on dMφ through LSD1/SNAIL1 pathway, subsequently leading to the decreased expression levels of Arg-1 and IL-10 via adenosine/A2AR/PKA/p-CREB/C/EBPβ pathway, which ultimately contributes to maternal-fetal tolerance dysfunction of dMφ.
Authors
- Xuemei Hu (ORCID: https://orcid.org/0000-0003-3584-5639)
- Jingjing Guo (ORCID: https://orcid.org/0000-0001-6139-4777)
- Aiqun Xu (ORCID: https://orcid.org/0000-0002-6830-7952)
- Han Zhang (ORCID: https://orcid.org/0000-0001-8809-4969)
- Lei Wei (ORCID: https://orcid.org/0000-0002-7768-0927)
- Shuai Li (ORCID: https://orcid.org/0000-0003-2545-7763)
- Junwei Wang (ORCID: https://orcid.org/0000-0001-9764-9524)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-2925-0295)
- Yuzhu Jiang (ORCID: https://orcid.org/0009-0003-7317-0254)
- Ruohan Yang (ORCID: https://orcid.org/0009-0008-8899-6477)
- Xiaohui Wang (ORCID: https://orcid.org/0009-0004-0884-8177)
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1186/s13071-025-06713-2
- Citations
- 1
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.05
Funders
- National Natural Science Foundation of China