An algorithm for annotation and classification of T. cruzi MASP sequences: towards a better understanding of the parasite genetic variability
This novel pipeline automates the annotation of MASPs, a key surface protein family unique to T. cruzi, improving genome annotation and enabling robust comparative analyses. It provides an essential tool for exploring the evolutionary dynamics of multigene families in T. cruzi and could be extended to other gene families.
Authors
- Carlos A. Buscaglia (ORCID: https://orcid.org/0000-0001-6466-4138)
- Virginia Balouz (ORCID: https://orcid.org/0000-0003-0724-4414)
- Aldana Alexandra Cepeda Dean
- Carlos Robello (ORCID: https://orcid.org/0000-0001-6985-6171)
- Luisa Berná (ORCID: https://orcid.org/0000-0002-9358-3414)
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad de la República de Uruguay (UY)
- National University of General San Martín (AR)
- Institut Pasteur de Montevideo (UY)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1186/s12864-025-11384-5
- Citations
- 5
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación