Therapeutic Mechanism of Zhuyang Tongbian Decoction in Treating Functional Constipation: Insights from a Pilot Study Utilizing 16S rRNA Sequencing, Metagenomics, and Metabolomics
ZTD notably improves intestinal flora composition and gut microbiota metabolic function, regulates SCFA levels, and reduces inflammation markers in FC patients. The strain Faecalibacterium_prausnitzii shows significant potential in regulation of intestinal inflammation and may play a crucial role in the treatment efficacy of ZTD for FC.
Authors
- Hang Yin (ORCID: https://orcid.org/0000-0002-3187-8874)
- Xuan Zhang (ORCID: https://orcid.org/0000-0002-9230-9210)
- Yang Xu (ORCID: https://orcid.org/0009-0009-5454-7320)
- Nan Sui (ORCID: https://orcid.org/0000-0002-3327-3174)
- Jie Kang (ORCID: https://orcid.org/0000-0003-4830-4217)
Institutions
- Liaoning University of Traditional Chinese Medicine (CN)
- Shenyang Anorectal Hospital (CN)
- General Hospital of Shenyang Military Region (CN)
- Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- International Journal of General Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/ijgm.s509592
- Citations
- 1
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.81
Funders
- National Natural Science Foundation of China