Presence of Tertiary Lymphoid Structures and Exhausted Tissue-Resident T Cells Determines Clinical Response to PD-1 Blockade in Renal Cell Carcinoma
We describe a paradigm wherein combined high TLS and low tissue-resident exhausted CD8+ T cells are required for optimal response to PD-1 blockade in RCC. This analysis identifies key determinants of response to PD-1 blockade in advanced RCC and suggests avenues for future immune modulation through rational combination therapy strategies.
Authors
- Lena Vanessa Wirth (ORCID: https://orcid.org/0000-0001-7776-2853)
- Kelly Street (ORCID: https://orcid.org/0000-0001-6379-5013)
- David F. McDermott (ORCID: https://orcid.org/0000-0002-2675-5095)
- Miya B. Hugaboom (ORCID: https://orcid.org/0000-0001-8099-3564)
- Thomas Denize (ORCID: https://orcid.org/0000-0002-8618-7691)
- Elizabeth R. Plimack (ORCID: https://orcid.org/0000-0002-7618-0744)
- Sayed Matar (ORCID: https://orcid.org/0000-0002-9687-2318)
- Naomi B. Haas (ORCID: https://orcid.org/0000-0001-8907-7968)
- Sabina Signoretti (ORCID: https://orcid.org/0000-0002-5000-9105)
- Catherine J. Wu (ORCID: https://orcid.org/0000-0002-3348-5054)
- Mehmet Asım Bilen (ORCID: https://orcid.org/0000-0003-4003-1103)
- Toni K. Choueiri (ORCID: https://orcid.org/0000-0002-9201-3217)
- Michael B. Atkins (ORCID: https://orcid.org/0000-0003-3901-9924)
- Valisha Shah (ORCID: https://orcid.org/0009-0000-7396-8184)
- Nourhan El Ahmar (ORCID: https://orcid.org/0000-0002-9348-204X)
- David A. Braun (ORCID: https://orcid.org/0000-0003-4543-5553)
- Robert Alter
- Mark N. Stein (ORCID: https://orcid.org/0000-0002-0853-3640)
- Nicholas R. Schindler (ORCID: https://orcid.org/0000-0003-2277-7729)
- Jacob Peter Zaemes (ORCID: https://orcid.org/0009-0007-4390-5490)
- Jeffrey A. Sosman (ORCID: https://orcid.org/0000-0002-0650-9698)
- Michael E. Hurwitz (ORCID: https://orcid.org/0000-0002-1326-7308)
- Destiny J. West (ORCID: https://orcid.org/0009-0004-5960-5271)
- Opeyemi A. Jegede (ORCID: https://orcid.org/0000-0003-1763-8214)
- Neil G. Ruthen (ORCID: https://orcid.org/0000-0002-4409-9503)
- Varunika Savla (ORCID: https://orcid.org/0009-0002-0281-5628)
- Hans J. Hammers (ORCID: https://orcid.org/0000-0002-6224-4559)
Institutions
- Northwestern University (US)
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- Fox Chase Cancer Center (US)
- Beth Israel Deaconess Medical Center (US)
- Hackensack University Medical Center (US)
- Harvard University (US)
- Emory University (US)
- Georgetown University (US)
- Cornell University (US)
- Columbia University Irving Medical Center (US)
- Georgetown University Medical Center (US)
- Keck Hospital of USC (US)
- Emory University Hospital (US)
- MedStar Georgetown University Hospital (US)
- Yale Cancer Center (US)
- University Medical Center (US)
- Yale University (US)
- Southwestern Medical Center (US)
- Dana-Farber Cancer Institute (US)
- Temple University Health System (US)
- Vince Lombardi Cancer Clinic (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Columbia University (US)
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0991
- Citations
- 23
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 24.04