Design and screening of novel molecular compounds targeting lactate dehydrogenase of Babesia microti
In this study, two compounds capable of inhibiting the growth of B. microti were obtained. Although both compounds showed moderate inhibitory activity against recombinant BmLDH (rBmLDH) and the growth of B. microti, there is potential to enhance their efficacy through further structural modifications, particularly of compound TB.
Authors
- Wanxin Luo (ORCID: https://orcid.org/0000-0001-6887-3682)
- Yuxin Yu (ORCID: https://orcid.org/0000-0003-4434-3016)
- Yidan Bai
- Shiyu Lu (ORCID: https://orcid.org/0000-0001-7685-684X)
- Sen Wang (ORCID: https://orcid.org/0000-0001-7179-626X)
- Dongfang Li (ORCID: https://orcid.org/0000-0001-8229-8258)
- Long Yu
- Yaxin Zheng
- Fangjie Li (ORCID: https://orcid.org/0000-0001-7683-3461)
- Junlong Zhao (ORCID: https://orcid.org/0000-0001-5162-4495)
- Zhen Han
- Lan He (ORCID: https://orcid.org/0000-0002-5453-4425)
Institutions
- Huazhong Agricultural University (CN)
- Center of Hubei Cooperative Innovation for Emissions Trading System (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-02-23
- DOI
- https://doi.org/10.1186/s13071-024-06623-9
- Citations
- 3
- Primary Topic
- Insect and Pesticide Research
- Type
- article
- Field-Weighted Citation Impact
- 5.02
Funders
- National Natural Science Foundation of China