LRP8 inhibits bladder cancer cell ferroptosis by activating the Wnt/β-catenin-SCD1 positive feedback loop
LRP8 mediates the synthesis of monounsaturated fatty acids through the Wnt/β-catenin-SCD1 positive feedback loop, thereby inhibiting ferroptosis in bc cells. These findings provide a promising target for the regulation of ferroptosis in bc cells.
Authors
- Guohong Shi
- Kaijun Liao
- Shihui Mao (ORCID: https://orcid.org/0000-0001-6282-4652)
- Xu Zhang (ORCID: https://orcid.org/0000-0002-4356-0281)
- Hao Xiong
- Zhongyuan Zhang (ORCID: https://orcid.org/0000-0002-8065-0198)
- Xiang Huang (ORCID: https://orcid.org/0000-0002-4456-5893)
- Yong Zhao
- Zhiqiang Feng
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Human Molecular Genetics
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1093/hmg/ddaf024
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52