Interfering with UBE2L3 expression targets regulation of MLKL to promote necroptosis inhibition of growth in osteosarcoma
UBE2L3 selectively binds to MLKL, exerting ubiquitination-mediated regulation on downstream MLKL. Decreased expression of UBE2L3 modulates MLKL expression and promotes necrosis, thereby inhibiting osteosarcoma growth.
Authors
- Xiwu Zhao (ORCID: https://orcid.org/0000-0001-6106-7389)
- Guoqiang Shan (ORCID: https://orcid.org/0000-0003-4619-1589)
- Hongwei Gao (ORCID: https://orcid.org/0000-0001-9179-750X)
- Mingzhi Gong (ORCID: https://orcid.org/0000-0003-1921-9187)
- Wenpeng Hui
- Deguo Xing
- Zhenggang Xiong
Institutions
- Shandong University (CN)
- Second Hospital of Shandong University (CN)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1186/s12957-025-03715-3
- Citations
- 1
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.81