Antibiotic‐induced decrease of bacterial load in guinea pig intestine reduces α<sub>2</sub>‐adrenoceptor expression and activity in peristaltic motor inhibition
Antibiotic-induced decrease of bacterial load in the small intestine selectively blunts the ability of α<sub>2</sub> agonists to impair peristalsis. This effect is explained by decreased α<sub>2</sub>-adrenoceptor expression, which may arise from TLR down-regulation in the dysbiotic gut.
Authors
- Peter Holzer (ORCID: https://orcid.org/0000-0002-5754-395X)
- Aitak Farzi (ORCID: https://orcid.org/0000-0001-9606-3871)
- Karl Kashofer (ORCID: https://orcid.org/0000-0002-5803-4014)
- Slave Trajanoski (ORCID: https://orcid.org/0000-0001-6667-8955)
- Eva Tatzl
- M. K. Herbert
Institutions
- Medical University of Graz (AT)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-02-23
- DOI
- https://doi.org/10.1111/bph.70001
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Medizinische Universität Graz