Transplantation of gastric epithelial mitochondria into human gastric cancer cells inhibits tumor growth and enhances chemosensitivity by reducing cancer stemness and modulating gastric cancer metabolism
Transplanting human gastric epithelial mitochondria downregulates gastric cancer mitochondrial biogenesis, glycolysis, GRP78-mediated cancer stemness, and increases oxidative stress, cell apoptosis under hypoxic conditions and chemosensitivity in response to 5-FU treatment. Moreover, the transplantation of epithelial mitochondria into gastric tumors inhibited the tumor growth in vivo tumor graft animal models. Therefore, mitochondrial transplantation can be considered for the treatment of gastric cancer.
Authors
- Kuen-Jang Tsai
- Yaw‐Bin Huang (ORCID: https://orcid.org/0000-0002-6024-0108)
- Hsin‐Yi Tsai (ORCID: https://orcid.org/0000-0001-8275-6132)
- Ming‐Wei Lin (ORCID: https://orcid.org/0000-0002-8880-5473)
- Deng-Chyang Wu
Institutions
- Kaohsiung Medical University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- E-Da Hospital (TW)
- I-Shou University (TW)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-23
- DOI
- https://doi.org/10.1186/s13287-025-04223-7
- Citations
- 6
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 5.62
Funders
- Ministry of Science and Technology, Taiwan
- Kaohsiung Medical University
- E-Da Hospital