OCT4 translationally promotes AKT signaling as an RNA-binding protein in stressed pluripotent stem cells
Our results reveal OCT4 as an anti-stress RBP for translational regulation that critically coordinates the survival and differentiation of PSCs in response to various stressors.
Authors
- Yi Zhang (ORCID: https://orcid.org/0000-0001-8170-9983)
- Bo Kang (ORCID: https://orcid.org/0000-0001-7864-252X)
- Shiqi She (ORCID: https://orcid.org/0000-0003-1658-0081)
- Yaxun Wei
- Qingyi Cao (ORCID: https://orcid.org/0000-0002-0644-1275)
- Xia Li (ORCID: https://orcid.org/0009-0001-5116-6890)
- Yisha Wang (ORCID: https://orcid.org/0000-0002-2933-6988)
- Songying Zhang (ORCID: https://orcid.org/0000-0001-8615-7196)
- Songsong Dan (ORCID: https://orcid.org/0000-0002-8132-1441)
- Yingjie Wang (ORCID: https://orcid.org/0000-0002-6888-9542)
- Xiaobing Zhang (ORCID: https://orcid.org/0000-0001-9300-7380)
- Wenxin Wang (ORCID: https://orcid.org/0000-0002-5053-0611)
- Xinyu Chen (ORCID: https://orcid.org/0000-0002-1181-8188)
- Wenjie Chen (ORCID: https://orcid.org/0000-0001-9512-9664)
- Chen Cheng (ORCID: https://orcid.org/0000-0002-0893-1948)
- Lina Shan (ORCID: https://orcid.org/0000-0002-5392-5299)
- Yanwen Zhou
- Yaqiang Xue
- Jianwen Hu
Institutions
- Central South University (CN)
- Sir Run Run Shaw Hospital (CN)
- Zhejiang Cancer Hospital (CN)
- Zhejiang Museum of Natural History (CN)
- Second Xiangya Hospital of Central South University (CN)
- Shaoxing People's Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
- Zhejiang University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-23
- DOI
- https://doi.org/10.1186/s13287-025-04229-1
- Citations
- 3
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China