Phylogenetic and Mutational Analysis of the Tax Gene in the Human T-Lymphotropic Virus 1-Associated HAM/TSP in Comparison with Asymptomatic Careers
All of the Iranian Tax proteins are under positive selection pressure with respect to Japanese isolates. Interestingly, we detect specific mutation patterns in the sequences. Positions 51, 82, 109, 172, 232, and 339 in the aa sequence have undergone mutations specific to Iranian HTLV-1; and in positions 22 and 146 aa we detected mutations unique to ACs and HAM/TSP, respectively.
Authors
- Sayed‐Hamidreza Mozhgani (ORCID: https://orcid.org/0000-0003-4570-2252)
- Seyed Mohammad Jazayeri (ORCID: https://orcid.org/0000-0002-2330-6921)
- Atefeh Bahavar (ORCID: https://orcid.org/0000-0002-4818-7973)
- Farzad Babakhani
- Ghazaleh Molaverdi
- Mohammad Ali Sahraian (ORCID: https://orcid.org/0000-0002-3224-8807)
- Sona Zare (ORCID: https://orcid.org/0000-0002-3109-6717)
- Mahdi Mohammaditabar (ORCID: https://orcid.org/0000-0001-9429-0632)
- Abbas Rahimi Foroushani (ORCID: https://orcid.org/0000-0002-3052-6420)
- Mehdi Norouzi (ORCID: https://orcid.org/0009-0000-9767-5941)
Institutions
- Golestan University (IR)
- University of Tehran (IR)
- Sina Hospital (IR)
- Jahrom University of Medical Sciences (IR)
- Golestan University of Medical Sciences (IR)
- Alborz University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Iranian Journal of Public Health
- Published
- 2025-02-23
- DOI
- https://doi.org/10.18502/ijph.v54i2.17914
- Citations
- 1
- Primary Topic
- T-cell and Retrovirus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.80