Utility of photoacoustic patterns in intra-operative margin assessment of breast cancer post neoadjuvant chemotherapy
US-PA provided clear visualization of tissue components, accurately correlating with histopathology. The method's high NPV minimizes the risk of re-operations and locoregional recurrence. Although the PPV was lower, it did not impact clinical management as surgeons typically excise wider margins in such cases. The study highlighted US-PA's potential as a promising tool for intraoperative margin assessment in BCS post-NACT, offering a rapid, accurate, and safe method. Further studies with larger sample sizes are needed to confirm these findings and enhance quantitative assessment methods.
Authors
- Thomas Choudary Putti (ORCID: https://orcid.org/0000-0001-8791-7257)
- Mikael Hartman (ORCID: https://orcid.org/0000-0001-5726-9965)
- Ghayathri Balasundaram (ORCID: https://orcid.org/0000-0002-2423-2821)
- Wei Qi Leong (ORCID: https://orcid.org/0000-0001-9188-3328)
- Eric Fang
- Hui Min Tan (ORCID: https://orcid.org/0000-0002-4833-7337)
- Serene Si Ning Goh (ORCID: https://orcid.org/0000-0003-4916-2142)
- Su Ann Lui (ORCID: https://orcid.org/0000-0003-4649-4184)
- Renzhe Bi (ORCID: https://orcid.org/0000-0001-7173-064X)
- Celene Wei Qi Ng (ORCID: https://orcid.org/0000-0003-2610-0264)
- Yonggeng Goh (ORCID: https://orcid.org/0000-0003-3149-0295)
- Malini Olivo (ORCID: https://orcid.org/0000-0002-1795-8683)
- Swee Tian Quek (ORCID: https://orcid.org/0000-0001-7561-7492)
- Shaik Ahmad Buhari
Institutions
- Agency for Science, Technology and Research (SG)
- National University Hospital (SG)
Publication Details
- Journal
- Photoacoustics
- Published
- 2025-02-23
- DOI
- https://doi.org/10.1016/j.pacs.2025.100701
- Citations
- 1
- Primary Topic
- Photoacoustic and Ultrasonic Imaging
- Type
- article
- Field-Weighted Citation Impact
- 0.67