Transcriptomic analysis of chronic chikungunya in the Reunionese CHIKGene cohort uncovers a shift in gene expression more than 10 years after infection
This study uncovers a shift in gene expression of CC subjects. IGHG3 and IGHV3-49 gene shut-offs spotlight the importance of neutralizing antibodies against chikungunya virus in the progression to chronic disease. Human diseases associations highlight connections to rheumatoid arthritis, nervous and cardiac systems. GSEA and WGCNA bounce the hypotheses of a persistent viral reservoir or an increased susceptibility to RNA viral pathogens with new onset infections. Together, our findings might offer potential targets for therapeutic options aimed at alleviating chronic chikungunya.
Authors
- Mano Joseph Mathew (ORCID: https://orcid.org/0000-0002-4930-6903)
- Hakim Hocini (ORCID: https://orcid.org/0000-0002-4972-3547)
- S. Porcherat
- Samir Medjane
- Sigrid Le Clerc
- Nora El Jahrani (ORCID: https://orcid.org/0000-0003-3570-1846)
- Raíssa Medina Santos (ORCID: https://orcid.org/0000-0002-1154-4308)
- Cécile Lefebvre (ORCID: https://orcid.org/0000-0002-6408-0201)
- Josselin Noirel (ORCID: https://orcid.org/0000-0001-6778-6966)
- Christine Fontaine
- Myriam Rahmouni (ORCID: https://orcid.org/0009-0003-6681-7136)
- Jean-Philippe Meyniel
- Adrien Maillot (ORCID: https://orcid.org/0000-0003-4430-4615)
- Jakub Savara (ORCID: https://orcid.org/0000-0003-3067-7867)
- Cécile Chabert
- Charles Cornet (ORCID: https://orcid.org/0000-0002-1363-7401)
- Patrick Gérardin
- Nathalie Ah-You
- Catherine Marimoutou
- Corinne Mussard
- Léa Bruneau
- Taoufik Labib
- Jean-François Zagury (ORCID: https://orcid.org/0000-0003-4309-9277)
- Jean-Louis Spadoni
- Christine Payet
Institutions
- Conservatoire National des Arts et Métiers (FR)
- Inserm (FR)
- Engineering School of Information and Digital Technologies (FR)
- Centre Hospitalier Universitaire de La Réunion (RE)
- Assistance Publique – Hôpitaux de Paris (FR)
- Génomique Bioinformatique et Applications (FR)
- HESAM Université (FR)
- Hôpital Albert-Chenevier (FR)
- Palacký University Olomouc (CZ)
Publication Details
- Journal
- Travel Medicine and Infectious Disease
- Published
- 2025-02-23
- DOI
- https://doi.org/10.1016/j.tmaid.2025.102825
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Conservatoire National des Arts et Métiers