Abstract IA03: Towards personalized minimally-invasive T-cell therapies

Abstract Ex vivo expansion of tumor-infiltrating lymphocytes can lead to durable tumor regression in patients with metastatic melanoma. Accumulating evidence suggests that TIL frequently recognize neoantigens and that neoantigen reactive TIL play an important role in the antitumor responses of patients treated with immune checkpoint blockade and TIL therapy. These are optimal targets for cancer immunotherapy as their expression is exquisitely confined to the tumor site, and T cells targeting these antigens have not undergone negative selection in the thymus. Despite the promising efficacy of TIL therapy against melanoma tumors, current research in the field focuses on trying to extend this efficacy to other tumor types. We will discuss the existing possibilities to develop personalized T-cell therapies targeting neoantigens for solid cancers, with particular emphasis on minimally invasive T-cell therapies. Citation Format: Alena Gros. Towards personalized minimally-invasive T-cell therapies [abstract]. In: Proceedings of the AACR IO Conference: Discovery and Innovation in Cancer Immunology: Revolutionizing Treatment through Immunotherapy; 2025 Feb 23-26; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Immunol Res 2025;13(2 Suppl):Abstract nr IA03.